Global, regional, and national causes of child mortality in a systematic analysis external icon. How best to estimate the global burden of pertussis external icon. Lancet Infect Dis. Pertussis in Latin America: epidemiology and control strategies external icon In English. Expert Rev Anti Infect Ther. International Bordetella pertussis assay standardization and harmonization meeting report external icon In English.
Analysis of Bordetella pertussis populations in European countries with different vaccination policies external icon In English. J Clin Microbiol , ;— Caro, G. I am also grateful to Laurence Langlais for her assistance. Potential conflicts of interest. Google Scholar. Google Preview. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account.
Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Isolation of B. The Origin of B. Pathogenesis of B. Genomic Variation of B. Can the Virulence of B. The Future of B. Bordetella pertussis and Pertussis Vaccines. Nicole Guiso Nicole Guiso.
Oxford Academic. Revision received:. Select Format Select format. Permissions Icon Permissions. Abstract Bordetella pertussis is a human-specific pathogen that causes whooping cough. Open in new tab Download slide. Google Scholar Crossref. Search ADS. Google Scholar PubMed. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis , and Bordetella bronchiseptica.
Speciation in the genus Bordetella as deduced from comparative genome analyses. Bordetella: molecular microbiology.
Bordetella pertussis , the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Polymorphism of Bordetella pertussis isolates circulating the last ten years in France, where a single effective whole-cell vaccine has been used for more than thirty years.
Pertussis in Algeria: direct and indirect methods of diagnosis- Analysis of the circulating isolates. Is Bordetella pertussis and parapertussis pathogenicity changing [abstract E1—10]?
Genomic content of Bordetella pertussis clinical isolates circulating in areas of intensive children vaccination. Characterization of adenylate cyclase-hemolysin gene duplication in a Bordetella pertussis isolate.
First report and detailed characterization of B. Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species. The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis -induced immunity. Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population. Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg between and with Russian vaccine strains.
Prevention of pertussis: recommendations derived from the second Global Pertussis Initiative roundtable meeting. Prevention of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants recommendations of the Advisory Committee on Immunization Practices ACIP. Issue Section:. Deaths are recorded every year in Europe, often are among infants who were too young to have been fully vaccinated. Less than one child in every thousand will die due to pertussis, however in many instances pertussis is not recognised as the cause of death, so it is possible that pertussis is responsible for a higher number of deaths than actually recorded.
Almost all deaths recorded in Europe are in infants younger than three months. Between and , an average of nine deaths per year were reported. It is difficult to compare the frequency of pertussis in different countries, because different methodologies for the diagnosis of pertussis are used.
Also, cough due to pertussis is often not recognised as such. The number of cases of pertussis reported to ECDC has been increasing since , reaching approximately 45 cases in Pertussis is primarily spread by breathing in droplets from the nose or throat of infected individuals.
Pertussis can even be spread by an individual who has only a mild form of pertussis or by an individual who is asymptomatic. Frequently, older siblings and parents who may be harbouring the bacteria bring the disease home and infect an infant in the household. Pertussis can occur at any age. There is an increasing number of adults and adolescents who are diagnosed with pertussis.
At present, the age groups with the most pertussis diagnoses are infants below one year of age, and adolescents between 10 and 20 years of age. All those not vaccinated against pertussis with the recommended number of doses of vaccine are at risk, regardless of age.
Unlike diseases such as chicken pox varicella and measles, it is possible to have pertussis more than once during a lifetime, because the antibodies that are developed after infection do not last over time. The most important way to prevent pertussis is through complete immunisation.
These bacteria attach to the cilia tiny, hair-like extensions that line part of the upper respiratory system. The bacteria release toxins poisons , which damage the cilia and cause airways to swell.
Pertussis is a very contagious disease only found in humans. Pertussis spreads from person to person. People with pertussis usually spread the disease to another person by coughing or sneezing or when spending a lot of time near one another where you share breathing space.
Many babies who get pertussis are infected by older siblings, parents, or caregivers who might not even know they have the disease.
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