People with diabetes have high levels of glucose sugar in their blood. Over time, having increased glucose levels can cause nerve damage. Symptoms of diabetic neuropathy include numbness, pain, tingling, or weakness in your hands or feet. Clinical studies have shown Cymbalta to be effective for treating pain from diabetic neuropathy. Researchers in one study randomly assigned adults with diabetic nerve pain to take either Cymbalta or a placebo every day for 12 weeks.
They assessed pain again after the study to compare how Cymbalta and a placebo affected pain. Cymbalta is FDA-approved to treat fibromyalgia. This is a chronic condition that can cause:. Fibromyalgia is often misdiagnosed and can be difficult to treat. Clinical studies have shown Cymbalta to be effective at treating fibromyalgia. One study compared Cymbalta with a placebo in adults with fibromyalgia. Before the study, these adults had an average pain score of 6.
People in the study took either Cymbalta or a placebo every day for 6 months. The researchers then measured their pain scores again to see if there was any improvement. Cymbalta is FDA-approved to treat chronic musculoskeletal pain. This refers to pain in the bones, muscles, ligaments, nerves, and tendons. Chronic pain is pain that lasts for more than 3 to 6 months. Clinical studies have shown Cymbalta to be effective for treating chronic musculoskeletal pain.
These studies involved adults with chronic low back pain or chronic pain caused by osteoarthritis a joint disorder that causes swelling and pain.
In one study , adults with chronic low back pain took either Cymbalta or a placebo every day for 13 weeks. Before the study, people rated their pain on a scale of 0 no pain to 10 worst pain possible. The researchers had people rate their pain again at the end of the study. Clinical studies have shown Cymbalta to be effective for treating these conditions in children.
Cymbalta belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs. It affects your levels of both serotonin and norepinephrine. SSRIs, on the other hand, only affect your serotonin levels. Controlled substances are medications that could cause either physical or mental dependence. With dependence , your body needs the drug to feel normal.
The Drug Enforcement Administration DEA sets limits on who can make, possess, and use medications that are controlled substances. However, Cymbalta could cause withdrawal symptoms if you stop taking the drug suddenly. Addiction is different from dependence. Over time, someone with addiction needs more and more of a drug to feel its effects. This is because the drug affects your central nervous system CNS. If you have questions or concerns about your risk for dependence with Cymbalta, talk with your doctor.
Cymbalta is approved to treat mood disorders, such as depression and anxiety. Because it affects your mood, some people report feeling calm or as if their mood is boosted while taking the drug. If you have questions about how Cymbalta may affect you, talk with your doctor or pharmacist. This was one of the more common side effects of the drug in clinical studies. In the studies:. If you have questions about side effects from Cymbalta, talk with your doctor or pharmacist.
You may wonder how Cymbalta compares with other medications that are prescribed for similar uses. Here we look at how Cymbalta and Lexapro are alike and different. Lexapro contains the active drug escitalopram. Lexapro belongs to a class of medications called selective serotonin reuptake inhibitors SSRIs. Both types of drugs are commonly used as antidepressants.
Cymbalta comes as capsule that you take by mouth. Cymbalta and Lexapro have some similar side effects and others that vary. Below are examples of these side effects. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Lexapro when taken individually :. These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs when taken individually.
The use of Cymbalta and Lexapro in treating depression in adults has been compared in a meta-analysis. A meta-analysis is a type of study that looks at the results of numerous clinical studies to see if there are any consistent results across the studies. In this meta-analysis , researchers looked at 16 different clinical studies that compared Cymbalta to other antidepressants, including three studies that compared Cymbalta with Lexapro.
The researchers found the two drugs to be similarly effective for treating depression. Cymbalta and Lexapro have also been compared in a meta-analysis for treating anxiety in adults. The researchers looked at 41 clinical studies involving a total of 11 antidepressants, including Cymbalta and Lexapro. They found Cymbalta and Lexapro to be similarly effective for treating anxiety.
According to estimates on GoodRx. Lexapro is available as a generic drug called escitalopram. Cymbalta and Effexor XR are prescribed for similar uses. Here we look at how these drugs are alike and different. Effexor XR contains the active drug venlafaxine ER. Duloxetine and venlafaxine ER both belong to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs.
This medication class is commonly used as antidepressants. Cymbalta and Effexor have some similar side effects and others that differ. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Effexor XR when taken individually :.
These lists contain examples of serious side effects that can occur with Cymbalta, with Effexor XR, or with both drugs when taken individually. The use of Cymbalta and Effexor XR in treating depression in adults has been compared in a meta-analysis. In this meta-analysis , researchers looked at 16 clinical studies comparing Cymbalta with other antidepressants , including three studies that compared Cymbalta with Effexor XR. A clinical study directly compared Cymbalta and Effexor XR for treating anxiety in adults.
In this study, the researchers randomly assigned people to take either Cymbalta, Effexor XR, or a placebo a treatment with no active drug once a day for 10 weeks. At the end of the study, the researchers found that people who took Cymbalta or Effexor XR had improved HAM-A scores compared with those who took a placebo.
They found Cymbalta and Effexor XR to be similarly effective for treating anxiety. Effexor XR is available as a generic drug called venlafaxine ER. Other drugs are available that can treat your condition. Some may be a better fit for you than others. They can tell you about other medications that may work well for you.
Note: Some of the drugs listed here are used off-label to treat these specific conditions. Examples of other drugs that may be used to treat depression include:. Examples of other drugs that may be used to treat anxiety include:. Examples of other drugs that may be used to treat diabetic neuropathy diabetic nerve pain include:. Examples of other drugs that may be used to treat fibromyalgia include:. Examples of other drugs that may be used to treat chronic musculoskeletal pain pain in the bones, muscles, ligaments, nerves, and tendons include:.
On its own, Cymbalta has caused liver damage and liver failure. In rare cases, this liver damage was fatal. Therefore, drinking heavily during your Cymbalta treatment could raise your risk for liver damage even more.
If you drink alcohol, talk with your doctor before you start taking Cymbalta. Depending on the amount of alcohol you consume, they may decide to have you try a different medication for your condition. Cymbalta belongs to a drug class called serotonin-norepinephrine reuptake inhibitors SNRIs. Cymbalta begins working as soon as you take your dose. It takes about 3 days for levels of the drug to become stable in your body. For example, in clinical trials , some adults with pain caused by diabetic neuropathy nerve damage , as well as some adults with fibromyalgia, noticed improvement within 1 week of starting the drug.
However, the National Alliance on Mental Illness notes that full improvement of depression symptoms may take up to 8 weeks. If you have questions about how Cymbalta works, or how long it takes to work, talk with your doctor or pharmacist. Cymbalta can interact with several other medications. It can also interact with certain supplements.
Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Below are lists of medications that can interact with Cymbalta. Before taking Cymbalta, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.
Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Cymbalta can increase serotonin levels in your body. Using Cymbalta with other drugs that also increase serotonin may raise your risk for serotonin syndrome. Serotonin syndrome is a rare but potentially life threatening condition. Taking multiple medications that increase serotonin levels could cause serotonin to build up to dangerous levels in your blood.
Before taking Cymbalta, be sure to tell your doctor if you take any of the medications listed above. They may want to monitor you for any signs of serotonin syndrome. Or they may have you take a different drug to treat your condition. Taking Cymbalta with these drugs may increase Cymbalta levels in your body.
Slowing down this process could raise your risk for side effects from Cymbalta. Certain drugs have stronger effects on these enzymes.
Examples of strong CYP1A2 inhibitors include:. Examples of CYP2D6 inhibitors include:. Before you take Cymbalta, be sure to tell your doctor if you take any of these medications. They can determine which drug is the best fit for you.
This means it can affect the levels of other drugs that are also broken down by this enzyme. However, some medications can cause side effects if their levels in your body are changed slightly. Examples of these drugs include:. If you need to take duloxetine during pregnancy to remain well, your doctor can explain the risks and the benefits to help you decide which treatment is best for you and your baby. For more information about how duloxetine can affect you and your baby during pregnancy, read the leaflet on the best use of medicines in pregnancy BUMPS website.
If your doctor or health visitor says your baby is healthy, duloxetine may be used during breastfeeding. Duloxetine passes into breast milk in very small amounts, but it's not known if it's harmful to the baby. It's important to continue taking duloxetine to keep you well.
Breastfeeding will also benefit both you and your baby. If you notice that your baby's not feeding as well as usual or seems unusually sleepy, or you have any other concerns about your baby, talk to your health visitor or doctor as soon as possible.
Some medicines and duloxetine can interfere with each other and increase the chances of you having side effects. Do not take the herbal remedy St John's wort while you're being treated with duloxetine, as this will increase your risk of side effects. Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.
Duloxetine is a type of antidepressant known as a serotonin-noradrenaline reuptake inhibitor SNRI. SNRIs are thought to work by increasing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain. You may see an improvement after 2 to 4 weeks. Improvements for nerve pain may take longer. Do not stop taking duloxetine after a week or two just because you feel it's not helping your symptoms.
Antidepressants like duloxetine help to gradually lift your mood so you feel better. You may notice that you sleep better and get on with people more easily because you're less anxious. Do not expect to feel better overnight, though. Some people feel worse during the first few weeks of treatment before they begin to feel better. If you're taking it for nerve pain or urinary incontinence, you may also notice some of these feelings.
For depression or anxiety - once you're feeling better, it's likely that you'll continue to take duloxetine for several more months. Most doctors recommend that you take antidepressants for 6 months to a year after you no longer feel depressed or anxious. Stopping your medicine too soon can make depression and anxiety come back. For nerve pain or urinary incontinence - if duloxetine is helping your symptoms, you can continue taking it long term. Your doctor may check that you're still having relief from the pain or urinary incontinence every few months.
If you have been feeling better for 6 months or more, your doctor may suggest coming off duloxetine. Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you have been taking duloxetine for a long time.
This is to help prevent any extra side effects you might get as a reaction to coming off the medicine. Do not stop taking duloxetine suddenly or without talking to your doctor first. Taking antidepressants, including duloxetine, is just one of many ways to treat depression and anxiety. If duloxetine is not working for you, speak to your doctor - there may be other treatments you can try. If you start to have problems with your weight while taking duloxetine, talk to your doctor or pharmacist.
During the first few days of taking duloxetine, it might be best to stop drinking alcohol until you see how the medicine affects you. There's no firm evidence to suggest that taking duloxetine will reduce fertility in either men or women. But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Speak to your doctor if you're planning to get pregnant while taking duloxetine.
Duloxetine will not affect any type of contraception, including the combined pill or emergency contraception. Some people cannot concentrate properly while they're taking duloxetine. When you first start taking duloxetine, it's a good idea to stop driving and cycling, and avoid using machines or tools, for the first few days until you know how this medicine makes you feel. Cannabis can affect the levels of duloxetine and make you more likely to get side effects.
Talk to your doctor if you think you might use recreational drugs while taking duloxetine. Page last reviewed: 31 January Next review due: 31 January Duloxetine On this page About duloxetine Key facts Who can and can't take it How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions.
About duloxetine Duloxetine is an antidepressant medicine. Duloxetine comes as capsules and is only available on prescription. Help us improve our website Can you answer a quick question about your visit today?
Duloxetine normally takes 2 to 4 weeks to work. Duloxetine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in activities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs.
In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein.
The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research. Your Journey Individuals with Mental Illness. Your Journey Family Members and Caregivers.
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