Loved the analogies and the content was very engaging. Just needs to be placed in a blog format, which I am sure you will do. Referencing would be ideal throughout the text. Great work! Good analogies with the coins and vending machine as well as the reference to movie villians when it is currently a trending topic. Very engaging title! I like the use of your vending machine analogy. However, I do think you should also include the different types of anatongonism: reversible competitive, irreversible competitive and non-competitive.
There will be plenty of diagrams online to demonstrate these also! I do suggest in your final submission to improve your layout for reader engagement. Also remember that you will be required to have in text referencing throughout! Full agonist opioids activate the opioid receptors in the brain fully resulting in the full opioid effect. Examples of full agonists are heroin, oxycodone, methadone, hydrocodone, morphine, opium and others.
Partial agonist opioids activate the opioid receptors in the brain, but to a much lesser degree than a full agonist. Buprenorphine is an example of a partial agonist. So the actions of the agonist are blocked by the presence of the antagonist in the receptor molecule. If someone is experiencing a potentially lethal morphine overdose, the opioid receptor antagonist naloxone can reverse the effects.
This is because naloxone marketed as Narcan quickly occupies all the opioid receptors in the body and prevents morphine from binding to and activating them. Morphine bounces in and out of the receptor in seconds. The effects of Narcan can be dramatic. Even if the overdose victim is unconscious or near death, they can become fully conscious and alert within seconds of injection.
Some drugs act to inhibit their action. Selective serotonin reuptake inhibitors SSRIs — such as the antidepressant fluoxetine Prozac — work like this. Serotonin is a brain neurotransmitter that regulates mood, sleep and other functions such as body temperature.
For the process to work smoothly, the brain must quickly turn off the signals coming from the serotonin soon after the chemicals are released from the terminals. Otherwise moment-to-moment control of brain and body function would be impossible. The brain does so with the help of serotonin transporters in the nerve terminal membrane. Because more serotonin molecules are then hanging around receptors for longer, they continue to stimulate them. We can crudely say the extra serotonin moderately turns up the volume of the signal to enhance positive mood.
These outside molecules bind to receptors on the cell, activating the receptor and generating a biochemical or electric signal inside the cell. This signal then makes the cell do certain things such as making us feel pain. Those molecules that bind to specific receptors and cause a process in the cell to become more active are called agonists. An agonist is something that causes a specific physiological response in the cell.
They can be natural or artificial. For instance, endorphins are natural agonists of opioid receptors. But morphine — or heroin that turns into morphine in the body — is an artificial agonist of the main opioid receptor.
Many drugs are made to mimic natural agonists so they can bind to their receptors and elicit the same — or much stronger — reaction. Simply put, an agonist is like the key that fits in the lock the receptor and turns it to open the door or send a biochemical or electrical signal to exert an effect.
0コメント