We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics. Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers. Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt , allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree.
Note that in some cases the trees are too large have too many nodes to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted. Please note: for large trees this can take some time.
While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded. The table below shows the structures on which the VHS domain has been found. There are 48 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.
Comments or questions on the site? Send a mail to pfam-help ebi. Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser. Loading page components …. Summary: VHS domain. Does Pfam agree with the content of the Wikipedia entry? Editing Wikipedia articles Before you edit for the first time Wikipedia is a free, online encyclopedia.
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Contact us The community annotation is a new facility of the Pfam web site. VHS protein domain Edit Wikipedia article VHS crystal structure of the vhs and fyve tandem domains of hrs, a protein involved in membrane trafficking and signal transduction.
FEBS Lett. PMID Biological process intracellular protein transport GO Each row contains the following information: the number of sequences which exhibit this architecture a textual description of the architecture, e.
Gla, EGF x 2, Trypsin. This example describes an architecture with one Gla domain, followed by two consecutive EGF domains, and finally a single Trypsin domain a link to the page in the Pfam site showing information about the sequence that the graphic describes the UniProt description of the protein sequence the number of residues in the sequence the Pfam graphic itself. Please note: full Pfam alignments can be very large. These HTML views are extremely large and often cause problems for browsers.
As for the standard HTML view, heatmap alignments can also be very large and slow to render. Reformatting You can download or view in your browser a text representation of a Pfam alignment in various formats: Selex Stockholm FASTA MSF You can also change the order in which sequences are listed in the alignment, change how insertions are represented, alter the characters that are used to represent gaps in sequences and, finally, choose whether to download the alignment or to view it in your browser directly.
Downloading You may find that large alignments cause problems for the viewers and the reformatting tool, so we also provide all alignments in Stockholm format. If you find these logos useful in your own work, please consider citing the following article: HMM Logos for visualization of protein families : B.
Schultz, S. Rahmann BMC Bioinformatics Curation and family details. Sunburst Tree Sunburst controls Hide. Weight segments by Change the size of the sunburst Small. Storing selection…. Currently selected: 0 sequences 0 species Note : selection tools show results in pop-up windows. Please disable pop-up blockers. How the sunburst is generated The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. We consider only the following eight major taxonomic levels: superkingdom kingdom phylum class order family genus species Colouring and labels Segments of the tree are coloured approximately according to their superkingdom.
Anomalies in the taxonomy tree There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place. Missing taxonomic levels Some species in the taxonomic tree may not have one or more of the main eight levels that we display. Unmapped species names The tree is built by looking at each sequence in the full alignment for the family. Sub-species Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown.
But before long, you may not be able to view them any longer. Because analog videos most likely your VHS tapes are rapidly deteriorating. As a result, most tapes have a shelf life of no more than 10 to 30 years, depending on how well they were stored.
The worst places are ones of high humidity or where mold can get to them. In time, a tape loses color, quality and crispness. Therefore, all those Christmases you recorded in the s and s may soon become unwatchable.
VCRs began catching on in the s, and dominated the home entertainment arena until the early s, when DVDs became the technology du jour. DVDs were followed by Blu-ray which — of course — was followed by streaming video. Fortunately, there are plenty of ways to digitize your much-cherished old home movies. According to CNET, a technology news and review site, there are several options to choose from — either online or at an electronic store — at various prices.
Beyond home movies, there are a whole lot of historical moments also at risk of being wiped out forever. You are leaving AARP. Please return to AARP. You'll start receiving the latest news, benefits, events, and programs related to AARP's mission to empower people to choose how they live as they age.
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